N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea

Base Information

• Chemical Name: N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea
• CAS No.: 1305317-24-1
• Molecular Formula: C₂₂H₁₉N₅S
• Molecular Weight: 385.492
• Mol file: 1305317-24-1.mol

Synonyms:

Chemical Property of N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea

There total 13 articles about N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

Ethyl isothiocyanate (542-85-8) + 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine (788821-74-9) → N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea (1305317-24-1)

Guidance literature:

With pyridine; for 24h; Reflux;

DOI:10.1055/s-0030-1259429

Reference yield:

4-aminopyridine (504-24-5) → N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea (1305317-24-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sulfuric acid; nitric acid / 5.5 h / 10 - 20 °C

2.1: sulfuric acid / 20 - 90 °C

3.1: potassium acetate; acetic acid / 1 h / 20 °C

3.2: 20 °C

4.1: water; tin(ll) chloride / ethanol / 2 h / Reflux

5.1: 1,4-dioxane / 4 h / Reflux

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 12 h / 100 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 48 h / 75 °C

8.1: pyridine / 24 h / Reflux

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sulfuric acid; hydroxylamine hydrochloride; water; nitric acid; potassium acetate; sodium acetate; acetic acid; tin(ll) chloride; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol; toluene; 6.1: Buchwald reaction;

DOI:10.1055/s-0030-1259429

Reference yield:

3,4-diaminopyridine (54-96-6) → N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea (1305317-24-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,4-dioxane / 120 h / Reflux

2: hydrogen bromide; dihydrogen peroxide / water / 1 h / 80 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 12 h / 100 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium acetate / methanol / 48 h / 75 °C

5: pyridine / 24 h / Reflux

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; hydroxylamine hydrochloride; hydrogen bromide; dihydrogen peroxide; sodium acetate; sodium t-butanolate; In 1,4-dioxane; methanol; water; toluene; 3: Buchwald reaction;

DOI:10.1055/s-0030-1259429

upstream raw materials:

4-aminopyridine

3,4-diaminopyridine

3,4,5-triaminopyridine

3,4-diamino-5-bromopyridine