2-amino-N,N-diethylbenzenesulfonamide

Base Information

• Chemical Name: 2-amino-N,N-diethylbenzenesulfonamide
• CAS No.: 57947-01-0
• Molecular Formula: C10H16N2O2S
• Molecular Weight: 228.315
• Hs Code.: 2935009090
• Mol file: 57947-01-0.mol

Synonyms:Benzenesulfonamide, o-amino-N,N-diethyl- (6CI);2-Amino-N,N-diethylbenzenesulfonamide;

Chemical Property of 2-amino-N,N-diethylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.06E-05mmHg at 25°C
• Melting Point: 68 °C(Solv: ethanol, 70% (64-17-5))
• Refractive Index: 1.56
• Boiling Point: 371.1 °C at 760 mmHg
• PKA: 0.28±0.10(Predicted)
• Flash Point: 178.2 °C
• PSA: 71.78000
• Density: 1.199 g/cm³
• LogP: 2.96130
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Diethyl2-Aminobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-N,N-diethylbenzenesulfonamide

There total 3 articles about 2-amino-N,N-diethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(N,N-diethylaminosulfonyl)nitrobenzene (77925-51-0) → 1-aminophenyl-2-sulphonic acid-diethyl amide (57947-01-0)

Guidance literature:

With lithium aluminium tetrahydride; titanium tetrachloride; In diethyl ether; at 20 ℃; for 0.416667h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.07.089

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → 1-aminophenyl-2-sulphonic acid-diethyl amide (57947-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / benzene / 0.5 h / 70 °C

2: 65 percent / iron; HCl / H₂O; ethanol / 0.5 h / Heating

With hydrogenchloride; iron; In ethanol; water; benzene; 1: Substitution / 2: Reduction;

Reference yield:

2-nitrobenzenediazonium chloride (119-66-4) → 1-aminophenyl-2-sulphonic acid-diethyl amide (57947-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: CuCl; SO₂

3: Raney nickel; ethanol / 36775.4 Torr / Hydrogenation

With ethanol; sulfur dioxide; nickel; copper(l) chloride;

upstream raw materials:

2-(N,N-diethylaminosulfonyl)nitrobenzene

2-Nitrobenzenesulfonyl chloride

2-nitrobenzenediazonium chloride

Downstream raw materials:

2-(N,N-Diethylaminosulfonyl)benzenesulfonamide

2-(N,N-diethylsulfamoyl)benzenesulfonyl chloride

Refernces

• 1、 Kornev,Zheltov. "Azo coupling of o- and p-(dialkylaminosulfonyl)benzene-diazonium salts with 7-acetylamino-4-hydroxynaphthalene-2-sulfonic acid in citrate-phosphate buffer solution". . p. 962 - 968. Retrieved 2007/10/03.
• 2、 -. "N(Substituted phenylsulfonyl) N'(substituted cyumidin-2-yl) ureas". . . Retrieved 2008/06/13.