3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

Base Information

• Chemical Name: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE
• CAS No.: 566205-01-4
• Molecular Formula: C4H2 Br2 Cl N3
• Molecular Weight: 287.341
• Hs Code.: 2933990090
• Mol file: 566205-01-4.mol

Synonyms:Pyrazinamine,3,5-dibromo-6-chloro- (9CI); 3,5-Dibromo-6-chloro-2-aminopyrazine

Chemical Property of 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

Chemical Property:

• Vapor Pressure: 0.000253mmHg at 25°C
• Boiling Point: 324oC at 760 mmHg
• PKA: -1.51±0.10(Predicted)
• Flash Point: 149.7oC
• PSA: 51.80000
• Density: 2.345g/cm3
• LogP: 2.81840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dibromo-6-chloro-2-pyrazinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

There total 1 articles about 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

2-amino-6-chloropyrazine (33332-28-4) → 3,5-dibromo-6-chloro-pyrazin-2-ylamine (566205-01-4)

Guidance literature:

With N-Bromosuccinimide; In water; acetonitrile; at 0 - 20 ℃; for 18h;

Reference yield: 92.0%

3,5-dibromo-6-chloro-pyrazin-2-ylamine (566205-01-4) + 4-fluorophenyl isothiocyanate (1544-68-9) → N-(3-fluorophenyl)-2-amino-6-bromo-5-chlorothiazolo[4,5-b]pyrazine (1427500-76-2)

Guidance literature:

3,5-dibromo-6-chloro-pyrazin-2-ylamine; With sodium hydroxide; In acetone; at 20 ℃; for 0.333333h; Inert atmosphere;

4-fluorophenyl isothiocyanate; In acetone; at 70 ℃; for 1h; Inert atmosphere;

DOI:10.5012/bkcs.2012.33.12.4271

Reference yield: 92.0%

3,5-dibromo-6-chloro-pyrazin-2-ylamine (566205-01-4) + 1-(isothiocyanatomethyl)-2,4-dimethoxy benzene (34966-97-7) → N-2-amino-6-bromo-5-chloro-(2,4-dimethoxybenzyl)thiazolo[4,5-b]pyrazine (1427500-75-1)

Guidance literature:

3,5-dibromo-6-chloro-pyrazin-2-ylamine; With sodium hydroxide; In acetone; at 20 ℃; for 0.333333h; Inert atmosphere;

1-(isothiocyanatomethyl)-2,4-dimethoxy benzene; In acetone; at 70 ℃; for 1h; Inert atmosphere;

DOI:10.5012/bkcs.2012.33.12.4271

upstream raw materials:

2-amino-6-chloropyrazine

Downstream raw materials:

2-amino-3-benzyl-5-bromo-6-chloropyrazine

N-phenyl-2-amino-6-bromo-5-chlorothiazolo[4,5-b]pyrazine

N-(3-fluorophenyl)-2-amino-6-bromo-5-chlorothiazolo[4,5-b]pyrazine

N-2-amino-6-bromo-5-chloro-(2,4-dimethoxybenzyl)thiazolo[4,5-b]pyrazine

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