Methotrimeprazine sulfoxide

Base Information

• Chemical Name: Methotrimeprazine sulfoxide
• CAS No.: 1188265-45-3
• Molecular Formula: C₁₉H₂₄N₂O₂S
• Molecular Weight: 344.478
• Mol file: 1188265-45-3.mol

Synonyms:

Chemical Property of Methotrimeprazine sulfoxide

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

racMethotrimeprazineSulfoxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Clinical Use: Treatment of schizophrenia Adjunctive treatment in palliative care Nausea and vomiting
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; increased hypotension and sedation with opioid analgesics; increased risk of ventricular arrhythmias with methadone. Anti-arrhythmics: increased risk of ventricular arrhythmias due to prolongation of QT interval; increased risk of ventricular arrhythmias with amiodarone, disopyramide and dronedarone - avoid. Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid. Antidepressants: possibly increased concentration of tricyclics, increased antimuscarinic effects and ventricular arrhythmias; avoid with MAOIs (2 fatalities have been reported); risk of ventricular arrhythmias with citalopram and escitalopram - avoid; possible increased risk of convulsions with vortioxetine. Anticonvulsant: lowers anticonvulsant threshold. Antihypertensives: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol. Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol. Antipsychotics: increased risk of ventricular arrhythmias with droperidol, pimozide and risperidone - avoid. Antivirals: concentration possibly increased by ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid. Anxiolytics and hypnotics: increased sedation. Atomoxetine: increased risk of ventricular arrhythmias. Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide. Diuretics: enhanced hypotensive effect. Lithium: increased risk of extrapyramidal effects and neurotoxicity. Pentamidine: increased risk of ventricular arrhythmias - avoid.

Technology Process of Methotrimeprazine sulfoxide

There total 4 articles about Methotrimeprazine sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Methotrimeprazine (851-68-3) → Methotrimeprazine sulfoxide (1188265-45-3,7052-08-6)

Guidance literature:

With oxygen; In methanol; at 20 ℃; Irradiation;

Reference yield: 71.0%

levomepromazine maleate (17086-29-2) → Methotrimeprazine sulfoxide (1188265-45-3,7052-08-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 5 ℃; for 0.5h;

DOI:10.1111/php.12147

Reference yield:

(±)-2-chloro-10-(3-dimethylamino-2-methylpropyl)phenothiazine (20828-91-5) → Methotrimeprazine sulfoxide (1188265-45-3,7052-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.25 h / 20 °C / Irradiation

2: methanol

In methanol;

DOI:10.1111/php.12147

upstream raw materials:

Methotrimeprazine

(±)-2-chloro-10-(3-dimethylamino-2-methylpropyl)phenothiazine

levomepromazine maleate

Downstream raw materials:

levomepromazine maleate