Technology Process of 3-benzyl-6-methoxybenzofuran
There total 3 articles about 3-benzyl-6-methoxybenzofuran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
di-μ-chlorotetrakis(ethene)diiridium(I); [(4S)-4-[5-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane;
In
para-xylene;
at 135 ℃;
for 24h;
Glovebox;
DOI:10.1002/chem.201602152
- Guidance literature:
-
With
copper;
at 220 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: bis(triphenylphosphine)palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
2: di-μ-chlorotetrakis(ethene)diiridium(I); [(4S)-4-[5-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane / para-xylene / 24 h / 135 °C / Glovebox
With
copper(l) iodide; bis(triphenylphosphine)palladium(II) chloride; di-μ-chlorotetrakis(ethene)diiridium(I); triethylamine; [(4S)-4-[5-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane;
In
tetrahydrofuran; para-xylene;
1: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201602152
