6-Chloro-4-methylpicolinonitrile

Base Information

• Chemical Name: 6-Chloro-4-methylpicolinonitrile
• CAS No.: 209858-74-2
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.583
• Hs Code.: 2933399090
• Mol file: 209858-74-2.mol

Synonyms:6-chloro-4-methylpyridine-2-carbonitrile;

Chemical Property of 6-Chloro-4-methylpicolinonitrile

Chemical Property:

• Vapor Pressure: 0.00314mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 283.6 °C at 760 mmHg
• PKA: -4.97±0.10(Predicted)
• Flash Point: 125.3 °C
• PSA: 36.68000
• Density: 1.26 g/cm³
• LogP: 1.91508
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

6-Chloro-4-methylpicolinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-4-methylpicolinonitrile

There total 7 articles about 6-Chloro-4-methylpicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-cyano-4-methylpyridine-1-oxide (170487-39-5) → 2-cyano-6-chloro-4-methyl pyridine (209858-74-2)

Guidance literature:

With trichlorophosphate; Reflux;

Reference yield:

sodium cyanide (773837-37-9) + 2-chloro-4-methylpyridin-N-oxide (52313-61-8) → 2-cyano-6-chloro-4-methyl pyridine (209858-74-2)

Guidance literature:

2-chloro-4-methylpyridin-N-oxide; With dimethyl sulfate;

sodium cyanide; In water; at -15 - -7 ℃; Inert atmosphere;

Reference yield:

2-chloro-4-methylpyridin-N-oxide (52313-61-8) → 2-cyano-6-chloro-4-methyl pyridine (209858-74-2)

Guidance literature:

With dimethyl sulfate; In water;

upstream raw materials:

2-chloro-4-methylpyridin-N-oxide

2-bromo-6-chloro-4-methylpyridine

sodium cyanide

2-chloro-4-picoline

Downstream raw materials:

6-chloro-4-methylpyridine-2-carboxylic acid