(2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:(2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:84110-18-9
Molecular Formula:C₃₃H₃₂Cl₃NO₈
Molecular Weight:676.978
Hs Code.:

(2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of (2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of (2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 7 articles about (2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84110-16-7
(1S,2R,5R)-2-[1-(4-Methoxy-phenyl)-ethyl]-6-oxa-3-aza-bicyclo[3.1.0]hexane

: 84110-18-9
(2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium trifluoroacetate, trifluoroacetic acid / 16 h / Heating

2: 10percent Na₂CO₃ / tetrahydrofuran / 1 h / 45 °C

3: pyridine / CH₂Cl₂ / 0.5 h / 3 - 5 °C

4: pyridine / 18 h

With pyridine; sodium 2,2,2-trifluoroacetate; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00358a003

Reference yield:

: (2S,3R,4R)-2-[1-(4-Methoxy-phenyl)-ethyl]-pyrrolidine-3,4-diol

: 84110-18-9
(2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 10percent Na₂CO₃ / tetrahydrofuran / 1 h / 45 °C

2: pyridine / CH₂Cl₂ / 0.5 h / 3 - 5 °C

3: pyridine / 18 h

With pyridine; sodium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00358a003

Reference yield:

: 84109-98-8
1-<(trichloroethoxy)carbonyl>-2-(α-methyl-p-methoxybenzyl)-3-pyrroline

: 84110-18-9
(2S,3R,4R)-3-Acetoxy-2-[1-(4-methoxy-phenyl)-ethyl]-4-(2,2,2-trichloro-ethoxycarbonyloxy)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 70percent perchloric acid, N-iodosuccinimide / tetrahydrofuran; H₂O / 1 h / 3 - 25 °C

2: 5percent KOH / ethanol / 0.5 h

3: 82 percent / HOAc, Zn / tetrahydrofuran / 1 h

4: sodium trifluoroacetate, trifluoroacetic acid / 16 h / Heating

5: 10percent Na₂CO₃ / tetrahydrofuran / 1 h / 45 °C

6: pyridine / CH₂Cl₂ / 0.5 h / 3 - 5 °C

7: pyridine / 18 h

With pyridine; potassium hydroxide; N-iodo-succinimide; perchloric acid; sodium 2,2,2-trifluoroacetate; sodium carbonate; acetic acid; trifluoroacetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00358a003