7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

Base Information

Chemical Name:7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on
CAS No.:116171-93-8
Molecular Formula:C₃₄H₃₉N₃O₃
Molecular Weight:537.702
Hs Code.:

7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

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Chemical Property of 7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

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Technology Process of 7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

There total 12 articles about 7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107688-23-3
2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol

: 116171-93-8
7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

Guidance literature:: Multi-step reaction with 10 steps

1: anhydrous sodium carbonate / tetrahydrofuran / 16 h / 50 °C

2: 98 percent / pyridine / 1 h / 40 °C

3: 98 percent / tetra-n-butyl ammonium bromide, sodium iodide / toluene / 2 h / Heating

4: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature

5: 77 percent / Amberlyst 15 / 120 h / 60 °C

6: sodium hydroxide, water, ethyl acetate, HCl / ethanol / 100 h / 100 °C

7: 95 percent / dicyclohexylcarbodiimide / ethyl acetate / 15 h / Ambient temperature

8: 69 percent / H₂, / 10percent Pd/C / ethyl acetate / 1 h / 40 - 50 °C

9: triethylamine, butylhypochlorit sol. / CH₂Cl₂; CCl₄

10: 1.) diethyl-ether bortrifluorate; 2.) sodium hydrogen carbonate sol. / 1.) 0 deg C, 1h; 2.) r.t. 20 min

With pyridine; hydrogenchloride; sodium hydroxide; Amberlyst 15; normal butyl hypochlorite; boron trifluoride diethyl etherate; tetrabutylammomium bromide; water; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; sodium carbonate; ethyl acetate; triethylamine; dicyclohexyl-carbodiimide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

: 107688-26-6,116260-70-9,116260-74-3
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaurenitril

: 116171-93-8
7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature

2: 77 percent / Amberlyst 15 / 120 h / 60 °C

3: sodium hydroxide, water, ethyl acetate, HCl / ethanol / 100 h / 100 °C

4: 95 percent / dicyclohexylcarbodiimide / ethyl acetate / 15 h / Ambient temperature

5: 69 percent / H₂, / 10percent Pd/C / ethyl acetate / 1 h / 40 - 50 °C

6: triethylamine, butylhypochlorit sol. / CH₂Cl₂; CCl₄

7: 1.) diethyl-ether bortrifluorate; 2.) sodium hydrogen carbonate sol. / 1.) 0 deg C, 1h; 2.) r.t. 20 min

With hydrogenchloride; sodium hydroxide; Amberlyst 15; normal butyl hypochlorite; boron trifluoride diethyl etherate; water; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; ethyl acetate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrachloromethane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

: 116171-86-9
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaeure

: 116171-93-8
7-benzyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-3,9-methano-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-15-on

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / dicyclohexylcarbodiimide / ethyl acetate / 15 h / Ambient temperature

2: 69 percent / H₂, / 10percent Pd/C / ethyl acetate / 1 h / 40 - 50 °C

3: triethylamine, butylhypochlorit sol. / CH₂Cl₂; CCl₄

4: 1.) diethyl-ether bortrifluorate; 2.) sodium hydrogen carbonate sol. / 1.) 0 deg C, 1h; 2.) r.t. 20 min

With normal butyl hypochlorite; boron trifluoride diethyl etherate; hydrogen; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrachloromethane; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)86863-0