1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

Base Information

• Chemical Name: 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine
• CAS No.: 157327-41-8
• Molecular Formula: C13H22 N2 O3
• Molecular Weight: 254.329
• Hs Code.: 2933399090
• Mol file: 157327-41-8.mol

Synonyms:3-[(Dimethylamino)methylene]-4-oxopiperidine-1-carboxylicacid tert-butyl ester; tert-Butyl3-[(dimethylamino)methylene]-4-oxo-1-piperidinecarboxylate

Chemical Property of 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

Chemical Property:

• Vapor Pressure: 2.65E-05mmHg at 25°C
• Melting Point: 85～87℃
• Boiling Point: 357.9oC at 760 mmHg
• PKA: 5.07±0.20(Predicted)
• Flash Point: 170.2oC
• PSA: 49.85000
• Density: 1.144g/cm3
• LogP: 1.57970
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine

There total 4 articles about 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate (157327-41-8,1202645-17-7)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield: 99.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate (157327-41-8,1202645-17-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 - 90 ℃;

Reference yield: 94.4%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate (157327-41-8,1202645-17-7)

Guidance literature:

In N,N-dimethyl acetamide; N,N-dimethyl-formamide; at 95 ℃; for 1.5h;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

N,N-dimethyl-formamide dimethyl acetal

tert-Butoxybis(dimethylamino)methane

N,N-dimethylformamide diethyl diacetal

Downstream raw materials:

5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride

2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylic acid tert-butyl ester

tert-butyl 2-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

tert-butyl 1-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate