3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide

Base Information

• Chemical Name: 3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide
• CAS No.: 1208005-10-0
• Molecular Formula: C₂₈H₂₇Cl₂FN₄O₄S
• Molecular Weight: 605.517
• Mol file: 1208005-10-0.mol

Synonyms:

Chemical Property of 3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide

There total 2 articles about 3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H29Cl2FN2O6S + 3-amino-pyrrolidin-2-one (2483-65-0) → 3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide (1208005-10-0,1208005-11-1,1208005-12-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 19h; Inert atmosphere;

Reference yield:

3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid (1161500-83-9) → 3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide (1208005-10-0,1208005-11-1,1208005-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1.5 h / -30 - 4 °C / Inert atmosphere

2: tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran;

Reference yield:

3-[{1[bis(4-Chlorophenyl)methyl]azetidin-3-yl}(methyl-sulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide (1208005-10-0,1208005-11-1,1208005-12-2) → (+)-3-[{1[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide + (-)-3-[{1[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-5-fluoro-N-(2-oxopyrrolidin-3-yl)benzamide

Guidance literature:

With a chiral stationary phase, Chiralpak IA 20 μm; In isopropyl alcohol; acetonitrile; Purification / work up; Resolution of racemate;

upstream raw materials:

3-amino-pyrrolidin-2-one

3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid