spiro[indene-1,4'-piperidine] hydrochloride

Base Information

• Chemical Name: spiro[indene-1,4'-piperidine] hydrochloride
• CAS No.: 137730-67-7
• Molecular Formula: C13H15 N . Cl H
• Molecular Weight: 221.73
• Hs Code.: 2933399990
• Mol file: 137730-67-7.mol

Synonyms:Spiro[1H-indene-1,4'-piperidine],hydrochloride (9CI); Spiro[indene-1,4'-piperidine] hydrochloride

Chemical Property of spiro[indene-1,4'-piperidine] hydrochloride

Chemical Property:

• Boiling Point: 350.4oC at 760 mmHg
• Flash Point: 165.7oC
• PSA: 12.03000
• LogP: 3.46540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Spiro[Indene-1,4''-Piperidine]Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of spiro[indene-1,4'-piperidine] hydrochloride

There total 2 articles about spiro[indene-1,4'-piperidine] hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> (137419-24-0) → spiro(1H-indene-1,4'-piperidine) hydrochloride (137730-67-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 0.5h;

DOI:10.1021/jm00089a013

Reference yield:

→ spiro(1H-indene-1,4'-piperidine) hydrochloride (137730-67-7)

Guidance literature:

Reference yield: 100.0%

methyl (RS)-N-phthaloyl-2-amino-4-pentenoate (133787-04-9) + spiro(1H-indene-1,4'-piperidine) hydrochloride (137730-67-7) → C26H26N2O4 (691877-48-2)

Guidance literature:

methyl (RS)-N-phthaloyl-2-amino-4-pentenoate; With ozone; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

spiro(1H-indene-1,4'-piperidine) hydrochloride; With sodium triacetoxyborohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃;

upstream raw materials:

1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine>

Downstream raw materials:

(1S)-1'-<<(7,7-dimethyl-2-oxobicyclo<2.2.1>hept-1-yl)methyl>-sulfonyl>spiro(1H-indene-1,4'-piperidine)