[5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine

Base Information

• Chemical Name: [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine
• CAS No.: 117280-13-4
• Molecular Formula: C₂₂H₂₁ClN₄S
• Molecular Weight: 408.955

Synonyms:

Chemical Property of [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine

Chemical Property:

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Technology Process of [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine

There total 11 articles about [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepine-2-thione (117280-12-3) → [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine (117280-13-4)

Guidance literature:

With hydrazine hydrate; In methanol; for 1h;

DOI:10.1016/0223-5234(96)85877-6

Reference yield:

3-(4-methylbenzoyl)propionic acid (4619-20-9) → [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine (117280-13-4)

Guidance literature:

Multi-step reaction with 10 steps

1: hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

2: NaBH₄, BF₃*OEt₂

3: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

4: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

5: CHCl₃ / 2 h / Heating

6: sodium iodide / tetrahydrofuran / 2 h / Heating

7: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

8: acetic acid / propan-2-ol / 20 h / Heating

9: P₂S₅ / CHCl₃ / 4 h / Heating

10: hydrazine hydrate / methanol / 1 h

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium hydroxide; sodium hypochlorite; sodium tetrahydroborate; tetraphosphorus decasulfide; boron trifluoride diethyl etherate; ammonia; sodium hydrogencarbonate; sulfur; hydrazine hydrate; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; methanol; chloroform; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/0223-5234(96)85877-6

Reference yield:

4-(4-methylphenyl)butan-1-ol (53392-07-7) → [5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine (117280-13-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

2: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

3: CHCl₃ / 2 h / Heating

4: sodium iodide / tetrahydrofuran / 2 h / Heating

5: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

6: acetic acid / propan-2-ol / 20 h / Heating

7: P₂S₅ / CHCl₃ / 4 h / Heating

8: hydrazine hydrate / methanol / 1 h

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; tetraphosphorus decasulfide; ammonia; sodium hydrogencarbonate; sulfur; hydrazine hydrate; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/0223-5234(96)85877-6

upstream raw materials:

5-(2-Chloro-phenyl)-7-(2-p-tolyl-ethyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepine-2-thione

3-(4-methylbenzoyl)propionic acid

4-(4-methylphenyl)butan-1-ol

4-(p-tolyl)butanal

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