2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile

Base Information

Chemical Name:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile
CAS No.:1616289-05-4
Molecular Formula:C₂₆H₂₅N₃O₃
Molecular Weight:427.503
Hs Code.:

Synonyms:

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Chemical Property of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile

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Technology Process of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile

There total 11 articles about 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616289-05-4
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: silver(l) oxide / toluene / 20 h / 110 °C

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

4.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: 14 h / 20 °C / Inert atmosphere

6.1: 1-methyl-pyrrolidin-2-one / 3 h / 190 °C

With methanol; sodium tetrahydroborate; thionyl chloride; sodium hydride; diisobutylaluminium hydride; silver(l) oxide; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 53475-53-9
2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile

: 1616289-05-4
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

2.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

4.2: 14 h / 20 °C / Inert atmosphere

5.1: 1-methyl-pyrrolidin-2-one / 3 h / 190 °C

With methanol; sodium tetrahydroborate; thionyl chloride; sodium hydride; diisobutylaluminium hydride; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 1616289-05-4
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; hydroxylamine hydrochloride / methanol / 24 h / 20 °C

2.1: triethylamine; dmap / dichloromethane / 14 h / 0 - 20 °C

3.1: methanesulfonyl chloride; boron trifluoride; titanium tetrachloride / methanol; dichloromethane / 14 h / 0 - 20 °C

4.1: sulfuric acid; N-iodo-succinimide / 14 h / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: 14 h / 20 °C / Inert atmosphere

6.1: 1-methyl-pyrrolidin-2-one / 3 h / 190 °C

With dmap; N-iodo-succinimide; sulfuric acid; boron trifluoride; hydroxylamine hydrochloride; titanium tetrachloride; sodium hydride; methanesulfonyl chloride; triethylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;