Ethyl 2-benzoyl-1-benzofuran-3-YL(methyl)carbamate

Base Information

• Chemical Name: Ethyl 2-benzoyl-1-benzofuran-3-YL(methyl)carbamate
• CAS No.: 301538-58-9
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• European Community (EC) Number: 668-452-7
• Mol file: 301538-58-9.mol

Synonyms:301538-58-9;Ethyl (2-benzoylbenzofuran-3-yl)(methyl)carbamate;ETHYL 2-BENZOYL-1-BENZOFURAN-3-YL(METHYL)CARBAMATE;AKOS024328494

Chemical Property of Ethyl 2-benzoyl-1-benzofuran-3-YL(methyl)carbamate

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 323.11575802
• Heavy Atom Count: 24
• Complexity: 460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)N(C)C1=C(OC2=CC=CC=C21)C(=O)C3=CC=CC=C3

Technology Process of Ethyl 2-benzoyl-1-benzofuran-3-YL(methyl)carbamate

There total 1 articles about Ethyl 2-benzoyl-1-benzofuran-3-YL(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-aminobenzo[b]furan-2-yl)phenylmethanone (49615-93-2) → Ethyl N-(2-benzoyl-1-benzofuran-3-yl)-N-methylcarbamate (301538-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 2 h / Heating

2: 77 percent / K₂CO₃ / acetonitrile / 24 h / Heating

With potassium carbonate; In acetonitrile; 1: Acylation / 2: Methylation;

DOI:10.1135/cccc20001093

Reference yield: 45.0%

Ethyl N-(2-benzoyl-1-benzofuran-3-yl)-N-methylcarbamate (301538-58-9) → N-Methyl-(2-benzoyl-1-benzofuran-3-yl)amine

Guidance literature:

With sodium hydroxide; In ethanol; for 40h; Heating;

DOI:10.1135/cccc20001093

upstream raw materials:

(3-aminobenzo[b]furan-2-yl)phenylmethanone