(S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

Base Information

Chemical Name:(S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid
CAS No.:123350-51-6
Molecular Formula:C₂HF₃O₂*C₂₇H₃₇N₇O₇
Molecular Weight:685.657
Hs Code.:

(S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

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Chemical Property of (S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

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Technology Process of (S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

There total 5 articles about (S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123362-96-9
{(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-2-((S)-1-methyl-2-oxo-piperidin-3-yl)-ethylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

: 123350-51-6
(S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((S)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.75h; Ambient temperature;
DOI:10.1021/jm00107a004

Reference yield:

: 123362-96-9
{(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

: 123350-51-6
(S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((R)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.75h; Ambient temperature;
DOI:10.1021/jm00107a004

Reference yield:

: C₂₂H₂₇N₅O₁₀

: 123350-51-6
(S)-2-Amino-N-[(1S,2S)-1-cyclohexylmethyl-2-hydroxy-2-((S)-1-methyl-2-oxo-piperidin-3-yl)-ethyl]-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / ethyl acetate; dimethylformamide / 1.) -23 deg C, 1 h, 2.) from 0 deg C to rt, 2.5 h

2: TFA / CH₂Cl₂ / 0.75 h / Ambient temperature

With 4-methyl-morpholine; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00107a004