2-Amino-3-fluoro-5-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine
• CAS No.: 852062-17-0
• Molecular Formula: C₆H₄F₄N₂
• Molecular Weight: 180.105
• Hs Code.: 2933399090
• Mol file: 852062-17-0.mol

Synonyms:3-fluoro-5-trifluoromethylpyridin-2-amine;2-AMINO-3-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;

Chemical Property of 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 1.2mmHg at 25°C
• Melting Point: 64-68℃
• Refractive Index: 1.459
• Boiling Point: 174.6 °C at 760 mmHg
• PKA: 1.60±0.49(Predicted)
• Flash Point: 59.4 °C
• PSA: 38.91000
• Density: 1.468 g/cm³
• LogP: 2.40290
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-fluoro-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine

There total 1 articles about 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

3-fluoro-5-trifluoromethylpyridine-2-carboxamide (852062-16-9) → 3-fluoro-5-trifluoromethylpyridin-2-amine (852062-17-0)

Guidance literature:

With potassium hydroxide; water; bromine; at 0 - 20 ℃; for 122h;

Reference yield:

3-fluoro-5-trifluoromethylpyridin-2-amine (852062-17-0) + 4-chlorosulfonyl-benzoic acid methyl ester (69812-51-7) → methyl 4-(N-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate (1254207-53-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2014.10.074

Reference yield:

3-fluoro-5-trifluoromethylpyridin-2-amine (852062-17-0) → 4-(N-benzyl-N-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid (1254205-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 80 °C

3: water; sodium hydroxide / tetrahydrofuran / 50 °C

With water; sodium hydride; caesium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.10.074

upstream raw materials:

3-fluoro-5-trifluoromethylpyridine-2-carboxamide

Downstream raw materials:

methyl 4-(N-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

4-(N-benzyl-N-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid

methyl 4-(N-benzyl-N-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

C₁₆H₁₀ClF₄N₃O₄S