4'-Amino-5'-methyl-p-toluenesulfon-o-anisidide

Base Information

• Chemical Name: 4'-Amino-5'-methyl-p-toluenesulfon-o-anisidide
• CAS No.: 91-70-3
• Molecular Formula: C₁₅H₁₈N₂O₃S
• Molecular Weight: 306.386
• Mol file: 91-70-3.mol

Synonyms:4-Amino-5-methyl-p-toluenesulfon-o-anisidide;N-(4-Amino-2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property of 4'-Amino-5'-methyl-p-toluenesulfon-o-anisidide

Chemical Property:

• Refractive Index: 1.617
• Boiling Point: 491.7 °C at 760 mmHg
• PKA: 10.79±0.10(Predicted)
• Flash Point: 251.2 °C
• PSA: 89.80000
• Density: 1.29 g/cm³
• LogP: 4.43000

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Amino-2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-Amino-5'-methyl-p-toluenesulfon-o-anisidide

There total 1 articles about 4'-Amino-5'-methyl-p-toluenesulfon-o-anisidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid-(2-methoxy-5-methyl-4-nitro-anilide) (170275-09-9) → toluene-4-sulfonic acid-(4-amino-2-methoxy-5-methyl-anilide) (91-70-3)

Guidance literature:

With hydrogenchloride; iron;

Reference yield:

toluene-4-sulfonic acid-(4-amino-2-methoxy-5-methyl-anilide) (91-70-3) → N'-(4-amino-5-methoxy-2-methyl-phenyl)-N,N-diphenyl-urea

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; chlorobenzene

2: aqueous sulfuric acid / 40 °C

With sulfuric acid; sodium hydrogencarbonate; chlorobenzene;

Reference yield:

toluene-4-sulfonic acid-(4-amino-2-methoxy-5-methyl-anilide) (91-70-3) + diphenylcarbamic chloride (83-01-2) → N,N-diphenyl-N'-[4-(toluene-4-sulfonylamino)-5-methoxy-2-methyl-phenyl]-urea (859737-25-0)

Guidance literature:

With sodium hydrogencarbonate; chlorobenzene;

upstream raw materials:

toluene-4-sulfonic acid-(2-methoxy-5-methyl-4-nitro-anilide)

Downstream raw materials:

N,N-diphenyl-N'-[4-(toluene-4-sulfonylamino)-5-methoxy-2-methyl-phenyl]-urea

Refernces

FLAVONOID PROFILES OF NEW ZEALAND LIBOCEDRUS AND RELATED GENERA

10.1016/0031-9422(90)85105-O

The research aimed to investigate the flavonoid compounds present in New Zealand Libocedrus species, specifically Libocedrus bidwillii and L. plumosa, and to assess their chemotaxonomic significance. The study's purpose was to support or challenge the existing classification of these species within the Cupressaceae family by analyzing their flavonoid profiles. The conclusions drawn from the research indicated that while the two Libocedrus species shared similar flavonoid types, they were distinct enough to be differentiated, with L. plumosa characterized by the presence of myricetin 3-rhamnoside and L. bidwillii by the presence of a di-acylated quercetin 3-rhamnoside. The chemicals used in the process included various flavonoids such as kaempferol, quercetin, apigenin, luteolin, amentoflavone, and biflavonoids like 7-O-methyl-2,3-dihydroamentoflavone.

Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75

10.1016/j.bmc.2014.04.016

The research focuses on the design and discovery of flavonoid-based HIV-1 integrase inhibitors that target both the active site of the enzyme and its interaction with LEDGF/p75. The purpose of this study is to develop novel inhibitors that can combat HIV-1 by inhibiting the viral replication process, specifically the integration of viral DNA into the host genome, which is catalyzed by HIV integrase (IN). The researchers synthesized a series of flavonoid derivatives with the aim of improving the inhibitory activity against IN and disrupting the IN-LEDGF/p75 interaction, which is crucial for viral integration. The study concluded that certain flavonoids, particularly those containing a catechol or β-ketoenol structure, showed potent inhibitory activity against both the catalytic function of IN and the IN-LEDGF/p75 interaction. Notably, the introduction of a hydrophilic morpholine group at the phenolic hydroxyl position resulted in sub- to low-micromolar IN-LEDGF/p75 inhibitory activity. The chemicals used in this process included various flavonoid derivatives, such as quercetin, baicalein, genistein, luteolin, chrysin, apigenin, and naringenin, along with synthetic reagents like acetic anhydride, benzyl bromide, potassium carbonate, and palladium catalysts for the synthesis and modification of these flavonoids.

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