Technology Process of Imagabalin
There total 6 articles about Imagabalin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3R,5S)-3-[benzyl-(1-phenyl-ethyl)-amino]-5-methyl-oct-6-enoic acid tert-butyl ester;
With
hydrogen;
palladium on carbon;
In
methanol;
for 23h;
under 2223.8 Torr;
With
trifluoroacetic acid;
In
dichloromethane;
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h
2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C
2.2: 3 h / -78 °C
3.1: hydrogen / palladium on carbon / methanol / 23 h / 2223.8 Torr
With
n-butyllithium; hydrogen; sodium hydride;
palladium on carbon;
In
tetrahydrofuran; methanol; hexanes; mineral oil;
