methyl 2-<2'(R and S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate

Base Information

• Chemical Name: methyl 2-<2'(R and S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate
• CAS No.: 95477-52-4
• Molecular Formula: C₁₆H₁₆Cl₄N₂O₄S
• Molecular Weight: 474.192
• Mol file: 95477-52-4.mol

Synonyms:

Chemical Property of methyl 2-<2'(R and S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-<2'(R and S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate

There total 2 articles about methyl 2-<2'(R and S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-phenoxy-4,5-dithia-2,7-diazabicyclo<4.2.0>oct-2-ene-8-one-7-isopropenyl acetate (59997-09-0) → methyl 2-<2'(R)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenyl butanoate (95477-52-4) + methyl 2-<2'(S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenyl butanoate (95477-52-4)

Guidance literature:

With sulfuryl dichloride; Title compound not separated from byproducts;

Reference yield:

methyl 3-phenoxy-4,5-dithia-2,7-diazabicyclo<4.2.0>oct-2-ene-8-one-7-isopropenyl acetate (59997-09-0) → methyl 2-<2'(R)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenyl butanoate (95477-52-4) + methyl 2-<2'(S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenyl butanoate (95477-52-4)

Guidance literature:

With sulfuryl dichloride; Title compound not separated from byproducts;

Reference yield: 55.0%

methyl 2-<2'(R and S)-chloro-4'-oxo-3'S-α-phenoxy-α-chloromethyleneiminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate (95477-52-4) → (S)-((S)-2-Methyl-thiiranyl)-((1R,5R)-7-oxo-3-phenoxy-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid methyl ester (131713-44-5)

Guidance literature:

With hydrogen sulfide; triethylamine; In tetrahydrofuran; 1.) -60 deg C, 30 min, 2.) 0 deg C, 0.5 h;

upstream raw materials:

methyl 3-phenoxy-4,5-dithia-2,7-diazabicyclo<4.2.0>oct-2-ene-8-one-7-isopropenyl acetate

Downstream raw materials:

(S)-((S)-2-Methyl-thiiranyl)-((1R,5R)-7-oxo-3-phenoxy-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid methyl ester

(Z)-4-Chloro-2-((R)-2-chloro-4-oxo-3-phenoxycarbonylamino-azetidin-1-yl)-3-methyl-but-2-enoic acid methyl ester

methyl-2-<2'R-chloro-4'-oxo-3'S-phenoxycarbonylaminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate

methyl-2-<2'S-chloro-4'-oxo-3'S-phenoxycarbonylaminoazetidin-1'-yl>-3-chloromethyl-3-chlorosulfenylbutanoate