2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Base Information

Chemical Name:2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid
CAS No.:1610371-61-3
Molecular Formula:C₃₁H₃₀FN₃O₄
Molecular Weight:527.595
Hs Code.:

2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Chemical Property of 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Technology Process of 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

There total 10 articles about 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-21-9
(4-bromophenyl)hydrazine

: 1610371-61-3
2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / ethanol / 12 h / 90 °C

2.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

2.2: 6 h / 80 °C / Inert atmosphere

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h

With chloro-trimethyl-silane; water; ethylene dibromide; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1610371-61-3
2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 0.33 h / 130 °C / Sealed tube; Microwave irradiation

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride; lithium bromide / tetrahydrofuran / 1.5 h / 0 °C

4.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

4.2: 6 h / 80 °C / Inert atmosphere

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; tetrabutylammomium bromide; water; sodium carbonate; methanesulfonyl chloride; ethylene dibromide; triethylamine; lithium bromide; sodium hydroxide; zinc; In tetrahydrofuran; methanol; water;

Reference yield:

: 1610371-63-5
3-hydroxy-2-methyl-1-(5-methylisoxazol-3-yl)prop-2-en-1-one

: 1610371-61-3
2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(5-methylisoxazol-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 2 h / 50 °C

2.1: trifluoroacetic acid / ethanol / 12 h / 90 °C

3.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

3.2: 6 h / 80 °C / Inert atmosphere

4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h

With chloro-trimethyl-silane; water; ethylene dibromide; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; toluene;