benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate

Base Information

• Chemical Name: benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate
• CAS No.: 1262439-64-4
• Molecular Formula: C₂₄H₂₇N₃O₅
• Molecular Weight: 437.495
• Mol file: 1262439-64-4.mol

Synonyms:

Chemical Property of benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate

There total 7 articles about benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-(4-methoxyphenyl)isoxazol-5-yl)methaneamine (338982-43-7) + Z-Val-OCO2iBu (41445-88-9) → benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate (1262439-64-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm1008715

Reference yield:

5-(azidomethyl)-3-(4-methoxyphenyl)isoxazole (1262439-59-7) → benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate (1262439-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Staudinger reaction / 1: Staudinger reaction;

DOI:10.1021/jm1008715

Reference yield:

(3-(4-methoxyphenyl)isoxazol-5-yl)methyl 4-methylbenzenesulfonate (1308264-80-3) → benzyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-methylpropyl carbamate (1262439-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Staudinger reaction / 2: Staudinger reaction;

DOI:10.1021/jm1008715

upstream raw materials:

p-methoxyl benzaldoxime

(3-(4-methoxyphenyl)isoxazol-5-yl)methyl 4-methylbenzenesulfonate

5-(azidomethyl)-3-(4-methoxyphenyl)isoxazole

1-(3-(4-methoxyphenyl)isoxazol-5-yl)methaneamine