2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Base Information

Chemical Name:2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester
CAS No.:101212-46-8
Molecular Formula:C₆₂H₇₆O₁₀SSi
Molecular Weight:1041.43
Hs Code.:

2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Chemical Property of 2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Technology Process of 2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

There total 43 articles about 2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6880-04-2
4-methoxy-3-methylbenzoic acid

: 101212-46-8
2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: SOCl₂ / diethyl ether

2: 2.) SOCl₂ / 2.) Et₂O

3: 90 percent / s-BuLi / 1.) Et₂O, 0 deg C, 2.) Et₂O

4: 2.) H₃O⁽¹⁺⁾ / 1.) THF

5: 1.) O₃, 2.) NEt₃ / 1.) CH₂Cl₂

6: DBU / benzene / 0.17 h

7: 0.08 h

8: DBU / benzene / 5 h / Heating

9: n-BuLi / tetrahydrofuran / 1 h / -80 °C

10: 2 h / Ambient temperature

With n-butyllithium; thionyl chloride; oxonium; sec.-butyllithium; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1039/c39850001326

Reference yield:

: 101212-39-9
5-methoxy-3,6-dimethyl-3-(prop-2'-enyl)phthalide

: 101212-46-8
2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) O₃, 2.) NEt₃ / 1.) CH₂Cl₂

2: DBU / benzene / 0.17 h

3: 0.08 h

4: DBU / benzene / 5 h / Heating

5: n-BuLi / tetrahydrofuran / 1 h / -80 °C

6: 2 h / Ambient temperature

With n-butyllithium; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1039/c39850001326

Reference yield:

: 112996-01-7
5-methoxy-3,6-dimethyl-3-formylmethylphthalide

: 101212-46-8
2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DBU / benzene / 0.17 h

2: 0.08 h

3: DBU / benzene / 5 h / Heating

4: n-BuLi / tetrahydrofuran / 1 h / -80 °C

5: 2 h / Ambient temperature

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; benzene;
DOI:10.1039/c39850001326