(E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:125473-42-9
Molecular Formula:C₃₆H₆₅NO₆SSi
Molecular Weight:668.067
Hs Code.:

(E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 5 articles about (E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125382-48-1
3-thexyldimethylsilyloxy-propionaldehyde

: 125416-26-4
10-dicyclohexylsulfamoyl-D-isobornyl (R)(+)-4-chlorophenylsulfinylacetate

: 125416-34-4
(E)-(R)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 125473-42-9
(E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With piperidine; In acetonitrile; at 25 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)99351-1

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 125473-42-9
(E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: quinoline / toluene / 52 h / 0 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min; 2.) THF, hexane, a.) -78 deg C, 45 min; b.) -23 deg C, 45 h

3: 22 percent Spectr_. / piperidine / acetonitrile / 25 °C

With piperidine; quinoline; lithium diisopropyl amide; In toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)99351-1

Reference yield:

: 121703-15-9
10-dicyclohexylsulfamoyl-D-isobornyl chloroformate

: 125473-42-9
(E)-(S)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-hydroxy-hex-2-enoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min; 2.) THF, hexane, a.) -78 deg C, 45 min; b.) -23 deg C, 45 h

2: 22 percent Spectr_. / piperidine / acetonitrile / 25 °C

With piperidine; lithium diisopropyl amide; In acetonitrile;
DOI:10.1016/S0040-4039(00)99351-1