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Technology Process of 3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone

3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone

Base Information
  • Chemical Name:3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone
  • CAS No.:215543-92-3
  • Molecular Formula:C17H16N2O3
  • Molecular Weight:296.32
  • Hs Code.:
  • DSSTox Substance ID:DTXSID90415361
  • Nikkaji Number:J850.997B
  • Wikidata:Q27097781,Q27132630
  • Pharos Ligand ID:P7QTY2P9P1BP
  • Metabolomics Workbench ID:62787,151704
  • ChEMBL ID:CHEMBL89363
  • Mol file:215543-92-3.mol
3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone

Synonyms:3-((3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene)-2-inolinone;SU 5402;Su-5402;SU5402

Suppliers and Price of 3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • SU 5402
  • 100mg
  • $ 1890.00
  • Usbiological
  • SU 5402
  • 1mg
  • $ 516.00
  • Usbiological
  • SU 5402
  • 2mg
  • $ 495.00
  • Usbiological
  • SU 5402
  • 500ug
  • $ 409.00
  • Usbiological
  • SU 5402
  • 1mg
  • $ 333.00
  • TRC
  • SU5402
  • 5mg
  • $ 65.00
  • Tocris
  • SU5402 ≥95%(HPLC)
  • 1
  • $ 258.00
  • Sigma-Aldrich
  • SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in the presence of 1 mM ATP).
  • 500 μg
  • $ 211.00
  • Sigma-Aldrich
  • SU5402
  • 500ug
  • $ 203.00
  • Sigma-Aldrich
  • SU5402 ≥98% (HPLC)
  • 5mg
  • $ 106.00
Total 38 raw suppliers
Chemical Property of 3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone
Chemical Property:
  • Appearance/Colour:Yellow-Green Solid 
  • Vapor Pressure:6.84E-15mmHg at 25°C 
  • Melting Point:>222 °C (dec.) 
  • Refractive Index:1.688 
  • Boiling Point:592.647 °C at 760 mmHg 
  • PKA:4.60±0.10(Predicted) 
  • Flash Point:312.222 °C 
  • PSA：82.19000 
  • Density:1.363 g/cm3 
  • LogP:2.97100 
  • Storage Temp.:0-6°C 
  • Solubility.:DMSO: soluble10mg/mL (clear solution) 
  • XLogP3:1.8
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:4
  • Exact Mass:296.11609238
  • Heavy Atom Count:22
  • Complexity:488
Purity/Quality:

99%, *data from raw suppliers

SU 5402 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
  • Isomeric SMILES:CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O
  • Description SU-5402 (215543-92-3) inhibits FGFR phosphorylation in vitro, in cell culture1, and in mouse tumor cell models2. SU-5402 can suppress ECP induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells via an FGFR3 dependent pathway.3
  • Uses A specific FGFR (fibroblast growth factor receptor er. SU 5402 is a specific FGFR (fibroblast growth factor receptor) inhibitor (1,2,3,4). It is also an intermediate for 3-(hetero)arylmethylidene-2-indolinone derivatives as modulators of protein kinase activity for use in treating cancer. SU5402 has been used as a fibroblast growth factor receptor inhibitor:in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assayto study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryosto study its effect on osteogenic markers.
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