Technology Process of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-4-yl)propyl)piperidin-3-yl)acetic acid
There total 2 articles about 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-4-yl)propyl)piperidin-3-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere
1.2: 3.17 h / 0 - 20 °C
2.1: sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 0.75 h / 20 °C
With
ruthenium trichloride; sodium periodate; sodium hydride;
In
tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ml500142b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 0.45 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere
2.2: 3.17 h / 0 - 20 °C
3.1: sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 0.75 h / 20 °C
With
ruthenium trichloride; sodium periodate; carbon tetrabromide; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ml500142b
