Chemical Property of Ku-0063794
Chemical Property:
- Vapor Pressure:3.09E-20mmHg at 25°C
- Refractive Index:1.609
- Boiling Point:694.3 °C at 760 mmHg
- PKA:14.20±0.10(Predicted)
- Flash Point:373.7 °C
- PSA：93.07000
- Density:1.248 g/cm3
- LogP:2.77290
- Storage Temp.:Store at RT
- Solubility.:DMSO: >2mg/mL (warmed)
- XLogP3:2.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:5
- Exact Mass:465.23760449
- Heavy Atom Count:34
- Complexity:643
- Purity/Quality:
-
99%, *data from raw suppliers
Ku 0063794 *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1CN(CC(O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
- Isomeric SMILES:C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
- Recent ClinicalTrials:Single Dose Study to Evaluate the Safety, and Efficacy of S-1226 (8%) in Subjects With Mild Atopic Asthma
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Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 10 nM). It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks. Ku-0063794 inhibits cell growth by inducing G1-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).
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Uses
Ku 0063794 is a specific mammalian target of rapamycin (mTOR) inhibitor and may be used for the treatment of cancers. KU 0063794 has been used: as a mammalian target of rapamycin (mTOR) inhibitor to study the effects of follicular stimulating hormone (FSH) in mTOR phosphorylation and vascular cell adhesion molecule-1 (VCAM-1) expression in?human umbilical vascular endothelial cells (HUVECs) as a mTOR inhibitor to treat effector memory (EM) CD8+ T cells for metabolic flux analysis as an autophagy inducer to demonstrate the utility of p62 and LC3B-II quantification in HEK293T cells and primary cultures of rat neurons and astrocytes using time-resolved fluorescence resonance energy transfer (TR-FRET)
