(1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

Base Information

Chemical Name:(1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester
CAS No.:75961-49-8
Molecular Formula:C₇₂H₈₆N₂O₁₀
Molecular Weight:1139.48
Hs Code.:

(1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

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Chemical Property of (1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

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Technology Process of (1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

There total 16 articles about (1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70863-80-8
9-((tetrahydro-2H-pyran-2-yl)oxy)nonan-1-al

: 75961-49-8,76022-94-1,76022-95-2,76022-96-3,76022-97-4,76022-98-5,76022-99-6,76023-00-2
(1R,2S,3R,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-butyllithium / 1) THF, hexane, -78 deg C, 45 min, 2) -78 deg C, 30 min

2: 62 percent / NaH / diethyl ether / 16 h / -10 - 25 °C

3: 2) toluenesulfonic acid monohydrate / 1) 31 h, reflux, xylene, 2) 24 h, room temp., methanol

4: 2) H₂O / 1) 3 h, reflux, pyridine, 2) 3 h, reflux, pyridine

5: benzene / 36 h / 18 °C / Irradiation

With n-butyllithium; water; sodium hydride; toluene-4-sulfonic acid; In diethyl ether; benzene;
DOI:10.1021/jo00316a027

Reference yield:

: 70863-80-8
9-((tetrahydro-2H-pyran-2-yl)oxy)nonan-1-al

: 75961-49-8,76022-94-1,76022-95-2,76022-96-3,76022-97-4,76022-98-5,76022-99-6,76023-00-2
(1R,2R,3S,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-butyllithium / 1) THF, hexane, -78 deg C, 45 min, 2) -78 deg C, 30 min

2: 62 percent / NaH / diethyl ether / 16 h / -10 - 25 °C

3: 2) toluenesulfonic acid monohydrate / 1) 31 h, reflux, xylene, 2) 24 h, room temp., methanol

4: 2) H₂O / 1) 3 h, reflux, pyridine, 2) 3 h, reflux, pyridine

5: benzene / 36 h / 18 °C / Irradiation

With n-butyllithium; water; sodium hydride; toluene-4-sulfonic acid; In diethyl ether; benzene;
DOI:10.1021/jo00316a027

Reference yield:

: 34957-73-8
methyl 9-hydroxynonanoate

: 75961-49-8,76022-94-1,76022-95-2,76022-96-3,76022-97-4,76022-98-5,76022-99-6,76023-00-2
(1R,2S,3R,4S)-3,4-Diphenyl-cyclobutane-1,2-dicarboxylic acid 1-[6-(6-oxo-5-{7-[(E)-(3-phenyl-acryloyl)oxy]-heptyl}-1,6-dihydro-pyridin-2-yl)-hexyl] ester 2-[7-(2-oxo-6-{6-[(E)-(3-phenyl-acryloyl)oxy]-hexyl}-1,2-dihydro-pyridin-3-yl)-heptyl] ester

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / conc.HCl / 22 h / Ambient temperature

2: 87 percent / diisobutylaluminum hydride / toluene; pentane / 2 h / -78 °C

3: 1) n-butyllithium / 1) THF, hexane, -78 deg C, 45 min, 2) -78 deg C, 30 min

4: 62 percent / NaH / diethyl ether / 16 h / -10 - 25 °C

5: 2) toluenesulfonic acid monohydrate / 1) 31 h, reflux, xylene, 2) 24 h, room temp., methanol

6: 2) H₂O / 1) 3 h, reflux, pyridine, 2) 3 h, reflux, pyridine

7: benzene / 36 h / 18 °C / Irradiation

With hydrogenchloride; n-butyllithium; water; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In diethyl ether; toluene; pentane; benzene;
DOI:10.1021/jo00316a027