Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
CAS No.:206650-15-9
Molecular Formula:C₂₄H₃₀N₂O₉
Molecular Weight:490.51
Hs Code.:

Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 9 articles about Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123122-48-5
(2R,3S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-ol

: 206650-15-9
Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / pyridine, CrO₃, Ac₂O / CH₂Cl₂ / 4 h

2: 1.) Zn, TiCl₄ / 1.) THF, 5 deg C, 4 d, 2.) THF, 1 h

3: 93 percent / NMO, pyridine, H₂O, OsO₄ / 2-methyl-propan-2-ol / 3 h / 76 °C

4: pyridine / 17 h

5: K₂CO₃, 18-crown-6 / dimethylformamide / 3 h / 65 °C

6: 57 percent / NaH / dimethylformamide / 1.) 30 min, 2.) r.t., 3 d

7: 85 percent / pyridine, DMAP / 48 h / Ambient temperature

8: 1.) BSA, 2.) TMS triflate / 1.) 1,2-dichloroethane, 78 deg C, 10 min, 2.) 1,2-dichloroethane, r.t., 63 h

With pyridine; chromium(VI) oxide; benzenesulfonamide; dmap; osmium(VIII) oxide; N-methyl-2-indolinone; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; water; acetic anhydride; titanium tetrachloride; sodium hydride; potassium carbonate; zinc; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 206650-07-9
tert-Butyl-((2S,5R)-5-methoxy-3-methylene-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane

: 206650-15-9
Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / NMO, pyridine, H₂O, OsO₄ / 2-methyl-propan-2-ol / 3 h / 76 °C

2: pyridine / 17 h

3: K₂CO₃, 18-crown-6 / dimethylformamide / 3 h / 65 °C

4: 57 percent / NaH / dimethylformamide / 1.) 30 min, 2.) r.t., 3 d

5: 85 percent / pyridine, DMAP / 48 h / Ambient temperature

6: 1.) BSA, 2.) TMS triflate / 1.) 1,2-dichloroethane, 78 deg C, 10 min, 2.) 1,2-dichloroethane, r.t., 63 h

With pyridine; benzenesulfonamide; dmap; osmium(VIII) oxide; N-methyl-2-indolinone; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; water; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 206650-05-7
(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methoxy-dihydro-furan-3-one

: 206650-15-9
Acetic acid (2R,3R)-2-acetoxymethyl-3-(2-benzyloxy-ethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Zn, TiCl₄ / 1.) THF, 5 deg C, 4 d, 2.) THF, 1 h

2: 93 percent / NMO, pyridine, H₂O, OsO₄ / 2-methyl-propan-2-ol / 3 h / 76 °C

3: pyridine / 17 h

4: K₂CO₃, 18-crown-6 / dimethylformamide / 3 h / 65 °C

5: 57 percent / NaH / dimethylformamide / 1.) 30 min, 2.) r.t., 3 d

6: 85 percent / pyridine, DMAP / 48 h / Ambient temperature

7: 1.) BSA, 2.) TMS triflate / 1.) 1,2-dichloroethane, 78 deg C, 10 min, 2.) 1,2-dichloroethane, r.t., 63 h

With pyridine; benzenesulfonamide; dmap; osmium(VIII) oxide; N-methyl-2-indolinone; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; water; titanium tetrachloride; sodium hydride; potassium carbonate; zinc; In N,N-dimethyl-formamide; tert-butyl alcohol;