3-Pyridinemethanamine,6-fluoro-(9CI)

Base Information

• Chemical Name: 3-Pyridinemethanamine,6-fluoro-(9CI)
• CAS No.: 205744-17-8
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.133
• Hs Code.: 2933399090
• Mol file: 205744-17-8.mol

Synonyms:1-(6-fluoropyridin-3-yl)methanamine;3-pyridinemethanamine, 6-fluoro-;

Chemical Property of 3-Pyridinemethanamine,6-fluoro-(9CI)

Chemical Property:

• Boiling Point: 231.9 °C at 760 mmHg
• PKA: 7.73±0.29(Predicted)
• Flash Point: 94 °C
• PSA: 38.91000
• Density: 1.18 g/cm³
• LogP: 1.37970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Fluoro-3-pyridinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Fluoro-3-pyridinemethanamine is a useful compound for the study of herbicidal activity of 2-cyano-3-[[(6-fluoro-3-pyridinyl)methyl]amino]acrylates.

Technology Process of 3-Pyridinemethanamine,6-fluoro-(9CI)

There total 5 articles about 3-Pyridinemethanamine,6-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-fluoro-3-pyridinecarbonitrile (3939-12-6) → 2-fluoropyridin-5-ylmethylamine (205744-17-8)

Guidance literature:

With ammonia; hydrogen; In methanol; at 20 ℃; for 12h;

Reference yield: 44.0%

N-(2-fluoro-5-pyridylmethyl)phthalimide (864061-60-9) → 2-fluoropyridin-5-ylmethylamine (205744-17-8)

Guidance literature:

N-(2-fluoro-5-pyridylmethyl)phthalimide; With hydrazine hydrate; In ethanol; for 5h; Heating;

With hydrogenchloride; In ethanol; for 0.5h; Heating;

DOI:10.1016/j.jfluchem.2004.12.015

Reference yield:

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 2-fluoropyridin-5-ylmethylamine (205744-17-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 45 percent / aq. HBF₄; NaNO₂ / 1 h / 0 - 50 °C

2.1: NBS; benzoyl peroxide / CCl₄ / 2 h / Heating

3.1: 7.53 g / dimethylformamide / 5 h / 20 °C

4.1: hydrazine hydrate / ethanol / 5 h / Heating

4.2: 44 percent / aq. HCl / ethanol / 0.5 h / Heating

With N-Bromosuccinimide; tetrafluoroboric acid; hydrazine hydrate; sodium nitrite; dibenzoyl peroxide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2004.12.015

upstream raw materials:

N-(2-fluoro-5-pyridylmethyl)phthalimide

(5-methyl-pyridin-2-yl)amine

2-fluoro-5-methylpyridine

5-(Bromomethyl)-2-fluoropyridine

Downstream raw materials:

C₂₄H₁₈FN₃O₃

C₂₄H₁₈FN₃O₃

C₂₅H₂₀FN₃O₃

Refernces

• 1、 Dong, Guoqiang,Chen, Wei,Wang, Xia,Yang, Xinglin,Xu, Tianying,Wang, Pei,Zhang, Wannian,Rao, Yu,Miao, Chaoyu,Sheng, Chunquan. "Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors". . p. 7965 - 7983. Retrieved 2017/10/18.