1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide

Base Information

• Chemical Name: 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
• CAS No.: 888719-03-7
• Molecular Formula: C25H16F2N4O3
• Molecular Weight: 458.424
• Mol file: 888719-03-7.mol

Synonyms:RS0065;3ce3;2-pyridone analogue,2;N-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

Chemical Property of 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide

Chemical Property:

• Melting Point: 212-214 °C
• Boiling Point: 701.5 °C at 760 mmHg
• PKA: 10.72±0.70(Predicted)
• Flash Point: 378.1 °C
• PSA: 89.01000
• Density: 1.497 g/cm³
• LogP: 5.10960

Purity/Quality:

97% ^*data from raw suppliers

N-(4-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide

There total 1 articles about 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-fluoro-4-((1H-pyrrolo [2,3-b]pyridin-4-yl)oxy)aniline (688781-75-1) + 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (868171-67-9) → N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (888719-03-7)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃;

DOI:10.1021/jm800476q

Reference yield: 99.0%

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (888719-03-7) → N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide hydrochloride (1052114-97-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; at 0 ℃; for 1.16667h;

DOI:10.1021/jm800476q

upstream raw materials:

3-fluoro-4-((1H-pyrrolo [2,3-b]pyridin-4-yl)oxy)aniline

1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Downstream raw materials:

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide hydrochloride

Refernces