N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide

Base Information

Chemical Name:N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide
CAS No.:154590-43-9
Molecular Formula:C₁₆H₂₁FN₄O₃
Molecular Weight:336.366
Hs Code.:
Mol file:154590-43-9.mol

Synonyms:N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide;

Suppliers and Price of N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide

Chemical Property:

Boiling Point:587.321 °C at 760 mmHg
Flash Point:309.001 °C
PSA：73.91000
Density:1.274 g/cm³
LogP:1.54630

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide

There total 23 articles about N-[[3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl]methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 174649-06-0
(S)-N-[[3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

: 154590-66-6,154590-43-9
(S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; under 760 Torr;
DOI:10.1016/j.tetlet.2006.07.065

Reference yield: 86.0%

: 154590-65-5
(S)-N-{[3-[3-fluoro-4-(N-4-tert-butoxycarbonylpiperazin-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl}acetamide

: 154590-66-6,154590-43-9
(S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2008.03.043

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 154590-66-6,154590-43-9
(S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyldiisopropylamine / acetonitrile / 80 °C

2.1: TEA / CH₂Cl₂ / 0 - 20 °C

3.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

4.1: NaHCO₃ / tetrahydrofuran

5.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C

5.2: tetrahydrofuran

6.1: TEA / CH₂Cl₂ / 0 - 20 °C

7.1: NaN₃ / dimethylformamide / 80 °C

8.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

9.1: TEA / CH₂Cl₂ / 0 - 20 °C

10.1: TFA / CH₂Cl₂ / 5 - 20 °C

With n-butyllithium; sodium azide; TEA; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.06.063