FMOC-GLU-OFM

Base Information

• Chemical Name: FMOC-GLU-OFM
• CAS No.: 200616-18-8
• Molecular Formula: C₃₄H₂₉NO₆
• Molecular Weight: 547.607
• Mol file: 200616-18-8.mol

Synonyms:Fmoc-Glu-OFm

Chemical Property of FMOC-GLU-OFM

Chemical Property:

• Boiling Point: 795.3±60.0 °C(Predicted)
• PKA: 4.44±0.10(Predicted)
• PSA: 101.93000
• Density: 1.303±0.06 g/cm3(Predicted)
• LogP: 6.50510
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-L-glutamic acid alpha-9-fluorenylmethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-GLU-OFM

There total 2 articles about FMOC-GLU-OFM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Glu(OtBu)-OFm → (S)-5-((9H-fluoren-9-yl)methoxy)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid (200616-18-8,252049-17-5)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 3h;

Reference yield:

9-Fluorenylmethanol (24324-17-2) + Fmoc-Glu(OtBu)-OH (71989-18-9) → (S)-5-((9H-fluoren-9-yl)methoxy)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid (200616-18-8,252049-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 8.5 h / 0 - 20 °C

2: trifluoroacetic acid / water / 3 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water;

upstream raw materials:

9-Fluorenylmethanol

Fmoc-Glu(OtBu)-OH