Serdemetan

Base Information

Chemical Name:Serdemetan
CAS No.:881202-45-5
Molecular Formula:C₂₁H₂₀N₄
Molecular Weight:328.417
Hs Code.:29339900
UNII:ID6YB4W3V8
ChEMBL ID:CHEMBL2137530
DSSTox Substance ID:DTXSID30236830
Metabolomics Workbench ID:153089
NCI Thesaurus Code:C77904
Nikkaji Number:J3.232.677C
Wikidata:Q27280666
Mol file:881202-45-5.mol

Synonyms:JNJ 26854165;JNJ-26854165;Serdemetan

Suppliers and Price of Serdemetan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
JNJ26854165
5mg
$ 145.00

TRC
JNJ26854165
10mg
$ 230.00

Matrix Scientific
N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine 95+%
250mg
$ 742.00

Matrix Scientific
N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine 95+%
1g
$ 1647.00

DC Chemicals
JNJ-26854165(Serdemetan) >98%
1 g
$ 1800.00

DC Chemicals
JNJ-26854165(Serdemetan) >98%
100 mg
$ 450.00

Crysdot
Serdemetan 98+%
10mg
$ 72.00

Crysdot
Serdemetan 98+%
50mg
$ 251.00

Crysdot
Serdemetan 98+%
100mg
$ 466.00

ChemScene
Serdemetan 99.23%
100mg
$ 858.00

Total 37 raw suppliers

Chemical Property of Serdemetan

Chemical Property:

Boiling Point:615.103 °C at 760 mmHg
Flash Point:325.803 °C
PSA：52.74000
Density:1.274g/cm³
LogP:5.10710
Solubility.:insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
XLogP3:4.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:328.16879665
Heavy Atom Count:25
Complexity:387

Purity/Quality:

99%, ^*data from raw suppliers

JNJ26854165 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
Recent ClinicalTrials:A Research Study of JNJ-26854165 to Determine the Safety and Dose in Patients With Advanced Stage or Refractory Solid Tumors.
Uses JNJ 26854165 is a p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor.

Technology Process of Serdemetan

There total 1 articles about Serdemetan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 881204-44-0
C₁₆H₁₇N₃

: 19524-06-2
4-bromopyridine hydrochloride

: 881202-45-5
N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine

Guidance literature:: C₁₆H₁₇N₃; 4-bromopyridine hydrochloride; With acetic acid; at 110 ℃; for 0.666667h;

With potassium carbonate; In water; at 0 ℃;