N¹-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide

Base Information

• Chemical Name: N¹-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide
• CAS No.: 1384054-49-2
• Molecular Formula: C₃₉H₄₀N₈O₄
• Molecular Weight: 684.798

Synonyms:

Chemical Property of N¹-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide

There total 6 articles about N¹-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

2-azidoethanamine trifluoroacetate + N1-(1-(4-([1,1′-biphenyl]-2-ylcarboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-(prop-2-yn-1-yl)-succinamide (1384054-36-7) → N1-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide (1384054-49-2)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In water; N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/jm3006146

Reference yield:

methyl 4-([1,1′-biphenyl]-2-ylcarboxamido)benzoate (180340-04-9) → N1-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide (1384054-49-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride; acetic acid / 4 h / Reflux

2.1: thionyl chloride / dichloromethane / 20 °C

2.2: 4 h / 0 °C

3.1: ammonium acetate; sodium cyanoborohydride / methanol / 100 °C / 750.08 Torr / Microwave irradiation

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; copper(ll) sulfate pentahydrate / water; N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; thionyl chloride; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; ammonium acetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm3006146

Reference yield:

4-[([1,1'-Biphenyl]-2-carbonyl)amino]benzoic Acid (168626-74-2) → N1-(1-(4-([1,1′-biphenyl]-2-yl-carboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)succinamide (1384054-49-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 20 °C

1.2: 4 h / 0 °C

2.1: ammonium acetate; sodium cyanoborohydride / methanol / 100 °C / 750.08 Torr / Microwave irradiation

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; copper(ll) sulfate pentahydrate / water; N,N-dimethyl-formamide / 5 h / 20 °C

With thionyl chloride; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; ammonium acetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm3006146

upstream raw materials:

4-methoxycarbonyl aniline

N¹-(1-(4-([1,1′-biphenyl]-2-ylcarboxamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N4-(prop-2-yn-1-yl)-succinamide

methyl 4-([1,1′-biphenyl]-2-ylcarboxamido)benzoate

4-[([1,1'-Biphenyl]-2-carbonyl)amino]benzoic Acid

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