(3R,2aS,9aS,9bS)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene

Base Information

Chemical Name:(3R*,2aS*,9aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene
CAS No.:124944-01-0
Molecular Formula:C₁₇H₂₁NO₂
Molecular Weight:271.359
Hs Code.:

(3R*,2aS*,9aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benz<cd>azulene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R*,2aS*,9aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene

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Technology Process of (3R*,2aS*,9aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene

There total 19 articles about (3R*,2aS*,9aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 124943-85-7,125073-08-7,125073-12-3,125073-14-5
2-Ethoxy-3-((E)-4-phenyl-but-3-enyl)-azepane-1-carboxylic acid tert-butyl ester

: 124944-01-0,125073-10-1
(9aR*,3S*,2aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene

Guidance literature:: With tin(IV) chloride; In dichloromethane; at -23 ℃; for 1h;
DOI:10.1021/jo00292a014

Reference yield: 76.0%

: 124943-85-7,125073-08-7,125073-12-3,125073-14-5
2-Ethoxy-3-((Z)-4-phenyl-but-3-enyl)-azepane-1-carboxylic acid tert-butyl ester

: 124944-01-0,125073-10-1
(3R*,2aS*,9aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene

Guidance literature:: With tin(IV) chloride; In dichloromethane; at -23 ℃; for 1h;
DOI:10.1021/jo00292a014

Reference yield:

: 10229-11-5
4-phenyl-but-3-yn-1-ol

: 124944-01-0,125073-10-1
(9aR*,3S*,2aS*,9bS*)-5a-Aza-2,2a,3,5,6,7,8,9,9a,9b-decahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene

Guidance literature:: Multi-step reaction with 7 steps

1: 2 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

2: pyridine / CHCl₃ / 8 h / Ambient temperature

3: NaI / acetone / 2 h / Heating

4: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C -> room temperature

5: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C -> room temperature

6: 1) Li(Et)3BH 2) HCl / 1) THF, -78 deg C 2) -78 deg C -> room temperature

7: 80 percent / SnCl₄ / CH₂Cl₂ / 1 h / -23 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; tin(IV) chloride; lithium triethylborohydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00292a014