2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
• CAS No.: 449758-77-4
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.24600
• Hs Code.: 2933998090
• Mol file: 449758-77-4.mol

Synonyms:1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid

Chemical Property of 2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

Chemical Property:

• PSA: 66.84000
• Density: 1.196
• LogP: 1.40840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-2-methylazetidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

There total 4 articles about 2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 1-(tert-butoxycarbonyl)-2-methylazetidine-2-carboxylic acid (449758-77-4,1198339-37-5) + (S)-Azetidin-2-carbonsaeuremethylester-hydrochlorid (69684-69-1,51020-00-9)

Guidance literature:

Reference yield: 89.0%

2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester (1391077-73-8) → 1-(tert-butoxycarbonyl)-2-methylazetidine-2-carboxylic acid (449758-77-4,1198339-37-5)

Guidance literature:

2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester; With water; sodium hydroxide; In ethanol; at 20 ℃; for 15h;

With citric acid; In ethanol; water; pH=5;

Reference yield:

2-[benzyl-(2-chloroethyl)amino]propionic acid ethyl ester (1391077-69-2) → 1-(tert-butoxycarbonyl)-2-methylazetidine-2-carboxylic acid (449758-77-4,1198339-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 24 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol / 15 h / 20 °C

3.2: pH 5

With water; hydrogen; potassium hexamethylsilazane; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene;

upstream raw materials:

2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

2-[benzyl-(2-chloroethyl)amino]propionic acid ethyl ester

1-benzyl-2-methylazetidine-2-carboxylic acid ethyl ester

Downstream raw materials:

(R)-2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester

2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester

4-[[(R)-1-(benzo[b]thiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-(3-chlorobenzyl)amino]butyric acid methyl ester

(R)-2-[(3-chloro-benzyl)-(3-methoxycarbonyl-propyl)-carbamoyl]-2-methyl-azetidine-1-carboxylic acid tert-butyl ester

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