Technology Process of Toluene-4-sulfonic acid (2S,3S)-2,3-dihydroxy-8-methyl-nonyl ester
There total 8 articles about Toluene-4-sulfonic acid (2S,3S)-2,3-dihydroxy-8-methyl-nonyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 12 percent / tetrahydrofuran / -50 °C
2: H2 / Pd/C / ethyl acetate; methanol / 24 h / 735.5 Torr / Ambient temperature
3: DMSO, (COCl)2, Et3N / CH2Cl2 / 1) 30 min, -70 deg C 2) 30 min, r.t.
4: K2CO3 / methanol / 5 h / Ambient temperature
5: NaBH4 / aq. ethanol / 10 h / Ambient temperature
6: pyridine / CH2Cl2 / 8 h / 0 °C
7: 70percent AcOH / methanol / 7 h / Ambient temperature
With
pyridine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)92629-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2 / Pd/C / ethyl acetate; methanol / 24 h / 735.5 Torr / Ambient temperature
2: DMSO, (COCl)2, Et3N / CH2Cl2 / 1) 30 min, -70 deg C 2) 30 min, r.t.
3: K2CO3 / methanol / 5 h / Ambient temperature
4: NaBH4 / aq. ethanol / 10 h / Ambient temperature
5: pyridine / CH2Cl2 / 8 h / 0 °C
6: 70percent AcOH / methanol / 7 h / Ambient temperature
With
pyridine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)92629-7
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 12 percent / tetrahydrofuran / -50 °C
2: H2 / Pd/C / ethyl acetate; methanol / 24 h / 735.5 Torr / Ambient temperature
3: DMSO, (COCl)2, Et3N / CH2Cl2 / 1) 30 min, -70 deg C 2) 30 min, r.t.
4: K2CO3 / methanol / 5 h / Ambient temperature
5: NaBH4 / aq. ethanol / 10 h / Ambient temperature
6: pyridine / CH2Cl2 / 8 h / 0 °C
7: 70percent AcOH / methanol / 7 h / Ambient temperature
With
pyridine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)92629-7
