N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide

Base Information

• Chemical Name: N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide
• CAS No.: 593960-11-3
• Molecular Formula: C14H16ClN3O4S2
• Molecular Weight: 389.88
• UNII: QS3XFL5JRX
• DSSTox Substance ID: DTXSID30425868
• Nikkaji Number: J2.843.799D
• Wikidata: Q27088391
• Pharos Ligand ID: ABANKG7J74DA
• Metabolomics Workbench ID: 150025
• ChEMBL ID: CHEMBL1229535
• Mol file: 593960-11-3.mol

Synonyms:PIK-93;593960-11-3;PIK 93;N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide;PIK93;N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide;CHEMBL1229535;N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE;PI-93;2chz;QS3XFL5JRX;Shokat PI3K/PI 93;D0S5YV;N-(5-{4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide;SCHEMBL48649;MLS006010977;GTPL6062;DTXSID30425868;BCPP000106;HMS3654F16;HMS3672K13;BCP01969;EX-A2137;BDBM50042924;s1489;AKOS016362896;CCG-264899;CS-0203;DB06836;SB19248;N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide;NCGC00346536-01;NCGC00346536-06;AC-32793;AS-16222;HY-12046;SMR004702780;FT-0761476;SW219245-1;D70986;J-523090;Q27088391;N-(5-(4-Chloranyl-3-(2-hydroxyethylsulfamoyl)phenyl)-4-methyl-1,3-thiazol-2-yl)ethanamide;N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazoly]acetamide;acetamide, N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-

Chemical Property of N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide

Chemical Property:

• Boiling Point: 611.8 °C at 760 mmHg
• Flash Point: 323.8 °C
• PSA: 148.50000
• Density: 1.48 g/cm³
• LogP: 4.12210
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble15mg/mL, clear
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 389.0270760
• Heavy Atom Count: 24
• Complexity: 543

Purity/Quality:

99%, ^*data from raw suppliers

PIK93 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO
• Description: PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM. PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ; IC50 = 19 nM). It is selective for PI4KIIIβ over PI4KIIIα and PI4KIIα (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells. It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.
• Uses: PIK 93 is a PI3Kγ and PI4KIIIβ inhibitor.

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