isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate

Base Information

• Chemical Name: isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate
• CAS No.: 1213233-62-5
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.391
• Mol file: 1213233-62-5.mol

Synonyms:

Chemical Property of isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate

There total 3 articles about isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-4-methyl-4H-oxazolin-5-one (51127-13-0,71963-72-9,87480-74-8,13302-43-7) → isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate (1213233-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 4.17 h / 0 °C

2: dmap / dichloromethane / 5 h / 20 °C

3: dmap / dichloromethane / 16 h

With dmap; triethylamine; In tetrahydrofuran; dichloromethane; 2: Steglich Rearrangement;

DOI:10.1055/s-0029-1217140

Reference yield:

4-methyl-2-phenyloxazol-5-yl benzoate (21819-71-6) → isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate (1213233-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 5 h / 20 °C

2: dmap / dichloromethane / 16 h

With dmap; In dichloromethane; 1: Steglich Rearrangement;

DOI:10.1055/s-0029-1217140

Reference yield:

rac-4-benzoyl-4-methyl-2-phenyloxazol-5-one (21819-72-7) + isopropyl alcohol (67-63-0,8013-70-5) → isopropyl rac-2-benzoylamino-2-methyl-3-oxo-3-phenylpropanoate (1213233-62-5)

Guidance literature:

With dmap; In dichloromethane; for 16h;

DOI:10.1055/s-0029-1217140

upstream raw materials:

4-methyl-2-phenyloxazol-5-yl benzoate

rac-4-benzoyl-4-methyl-2-phenyloxazol-5-one

isopropyl alcohol

2-phenyl-4-methyl-4H-oxazolin-5-one