Saredutant

Base Information

• Chemical Name: Saredutant
• CAS No.: 159125-41-4
• Molecular Formula: C₃₁H₃₅Cl₂N₃O₂
• Molecular Weight: 552.544
• Mol file: 159125-41-4.mol

Synonyms:SR 48212A;Saredutant;N-[4-[4-(Acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide;

Chemical Property of Saredutant

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 734.669 °C at 760 mmHg
• PKA: 15.88±0.20(Predicted)
• Flash Point: 398.114 °C
• PSA: 56.14000
• Density: 1.26 g/cm³
• LogP: 7.14490

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Saredutant

There total 8 articles about Saredutant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-but-2-enedioic acid (110-17-8,26099-09-2) + N-(4-phenylpiperidin-4-yl)acetamide (146396-04-5) → SR 48212A (142001-63-6,159125-41-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In dichloromethane; water; potassium carbonate; acetone; acetonitrile;

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → SR 48212A (142001-63-6,159125-41-4)

Guidance literature:

Multi-step reaction with 6 steps

1: NaH / dimethylformamide

2: H₂ / Raney nickel / acidic solution

3: BH₃ / tetrahydrofuran

4: NEt₃ / CH₂Cl₂ / 20 °C

5: NEt₃ / CH₂Cl₂

6: K₂CO₃ / dimethylformamide

With borane; hydrogen; sodium hydride; potassium carbonate; triethylamine; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00343-3

Reference yield:

α-[2-(Tetrahydropyran-2-yloxy)ethyl]-3,4-dichlorophenyl-acetonitrile (135936-16-2) → SR 48212A (142001-63-6,159125-41-4)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Raney nickel / acidic solution

2: BH₃ / tetrahydrofuran

3: NEt₃ / CH₂Cl₂ / 20 °C

4: NEt₃ / CH₂Cl₂

5: K₂CO₃ / dimethylformamide

With borane; hydrogen; potassium carbonate; triethylamine; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00343-3

upstream raw materials:

N-(4-phenylpiperidin-4-yl)acetamide

N-[2-(3,4-dichlorophenyl)-3-formylpropyl]-N-methylbenzamide

N-[2-(3,4-dichlorophenyl)-4-[(methylsulfonyl)oxy]butyl]-N-methyl benzamide

3,4-dichloro-benzeneacetonitrile