6-chloro-2-hydroxyisophorone

Base Information

• Chemical Name: 6-chloro-2-hydroxyisophorone
• CAS No.: 97041-22-0
• Molecular Formula: C₉H₁₃ClO₂
• Molecular Weight: 188.654
• Mol file: 97041-22-0.mol

Synonyms:

Chemical Property of 6-chloro-2-hydroxyisophorone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-hydroxyisophorone

There total 2 articles about 6-chloro-2-hydroxyisophorone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

3-Chloro-3,5,5-trimethyl-cyclohexane-1,2-dione (97041-24-2) → 6-chloro-2-hydroxyisophorone (97041-22-0) + 3,6-dichloro-2-hydroxy-4,4,6-trimethyl-2-cyclohexenone (97041-23-1)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; at 20 ℃; for 48h; reflux in CCl₄, 2 h;

Reference yield:

2-hydroxy-3,5,5-trimethylcyclohex-2-ene-1-one (4883-60-7) → 6-chloro-2-hydroxyisophorone (97041-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₂ / CH₂Cl₂ / 4 - 15 °C / var. temp.

2: 83 percent / HCl / dimethylformamide / 48 h / 20 °C / reflux in CCl₄, 2 h

With hydrogenchloride; chlorine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 87.0%

6-chloro-2-hydroxyisophorone (97041-22-0) → 3,6-dichloro-2-hydroxy-4,4,6-trimethyl-2-cyclohexenone (97041-23-1)

Guidance literature:

With chlorine; 1) CH₂Cl₂, 20 to 29 deg C, 15 min, 2) DMF, CH₂Cl₂, reflux, 30 min;

upstream raw materials:

3-Chloro-3,5,5-trimethyl-cyclohexane-1,2-dione

2-hydroxy-3,5,5-trimethylcyclohex-2-ene-1-one

Downstream raw materials:

3,6-dichloro-2-hydroxy-4,4,6-trimethyl-2-cyclohexenone