5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE

Base Information

• Chemical Name: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE
• CAS No.: 914349-75-0
• Molecular Formula: C12H7 F N2
• Molecular Weight: 198.19600
• Hs Code.: 2933399990
• Mol file: 914349-75-0.mol

Synonyms:5-(4-fluorophenyl)picolinonitrile;

Chemical Property of 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE

Chemical Property:

• Vapor Pressure: 2.36E-05mmHg at 25°C
• Boiling Point: 359.5oC at 760 mmHg
• Flash Point: 171.2oC
• PSA: 36.68000
• Density: 1.25g/cm3
• LogP: 2.75938
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(4-Fluorophenyl)pyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE

There total 2 articles about 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoroboronic acid (1765-93-1) + 2-Cyano-5-bromopyridine (97483-77-7) → 5-(4-fluorophenyl)picolinonitrile (914349-75-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/tx500256j

Reference yield:

→ 5-(4-fluorophenyl)picolinonitrile (914349-75-0)

Guidance literature:

Reference yield:

5-(4-fluorophenyl)picolinonitrile (914349-75-0) → (5-(4-fluorophenyl)pyridin-2-yl)methanamine (1158763-65-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ethanol-dry ice;

DOI:10.1016/j.bmcl.2016.08.018

upstream raw materials:

4-fluoroboronic acid

2-Cyano-5-bromopyridine

Downstream raw materials:

(5-(4-fluorophenyl)pyridin-2-yl)methanamine

5-bromo-N-((5-(4-fluorophenyl)pyridin-2-yl)methyl)-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

5-bromo-N-((5-(4-fluorophenyl)pyridin-2-yl)methyl)-1H-indole-2-sulfonamide

Refernces

• 1、 Sinha, Sarmistha,Ahire, Deepak,Wagh, Santosh,Mullick, Dibakar,Sistla, Ramesh,Selvakumar, Kumaravel,Cortes, Janet Caceres,Putlur, Siva Prasad,Mandlekar, Sandhya,Johnson, Benjamin M.. "Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: A chemical model to describe the formation of thiazoline derivatives in human liver microsomes". . p. 2052 - 2061. Retrieved 2015/02/19.