3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide

Base Information

Chemical Name:3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide
CAS No.:1359754-82-7
Molecular Formula:C₂₂H₁₇N₅O₂
Molecular Weight:383.409
Hs Code.:

Synonyms:

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Chemical Property of 3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide

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Technology Process of 3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide

There total 6 articles about 3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₁₆N₄O₃

: 1359754-82-7
3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide

Guidance literature:: With ammonium acetate; In N,N-dimethyl-formamide; at 140 ℃; for 2h;
DOI:10.1039/c1cc15851a

Reference yield:

: 1359754-86-1
3-(1H-indol-3-yl)-1-methyl-4-((trimethylsilyl)ethynyl)-1H-pyrrole-2,5-dione

: 1359754-82-7
3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol

2.1: copper(ll) sulfate pentahydrate; ascorbic acid sodium salt / tetrahydrofuran; methanol / 20 °C

3.1: water; potassium hydroxide / ethanol / 2 h

3.2: 20 °C / pH 1

4.1: ammonium acetate / N,N-dimethyl-formamide / 2 h / 140 °C

With copper(ll) sulfate pentahydrate; ascorbic acid sodium salt; ammonium acetate; tetrabutyl ammonium fluoride; water; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c1cc15851a

Reference yield:

: 120-72-9
indole

: 1359754-82-7
3-(1H-indol-3-yl)-4-(1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl)-maleimide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 60 °C

1.2: 1 h / 65 °C

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol

4.1: copper(ll) sulfate pentahydrate; ascorbic acid sodium salt / tetrahydrofuran; methanol / 20 °C

5.1: water; potassium hydroxide / ethanol / 2 h

5.2: 20 °C / pH 1

6.1: ammonium acetate / N,N-dimethyl-formamide / 2 h / 140 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; ascorbic acid sodium salt; ethylmagnesium bromide; ammonium acetate; tetrabutyl ammonium fluoride; water; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 2.1: Sonogashira coupling;
DOI:10.1039/c1cc15851a