4-IODOISOQUINOLINE

Base Information

• Chemical Name: 4-IODOISOQUINOLINE
• CAS No.: 55270-33-2
• Molecular Formula: C9H6 I N
• Molecular Weight: 255.058
• Hs Code.: 2933499090
• Mol file: 55270-33-2.mol

Synonyms:4-Iodoisoquinoline

Chemical Property of 4-IODOISOQUINOLINE

Chemical Property:

• Melting Point: 93-94 °C
• Boiling Point: 336.8±15.0 °C(Predicted)
• PKA: 3.49±0.10(Predicted)
• PSA: 12.89000
• Density: 1.837
• LogP: 2.83940
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

4-Iodoisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODOISOQUINOLINE

There total 6 articles about 4-IODOISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

isoquinoline (119-65-3) → 4-iodo-isoquinoline (55270-33-2)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In decane; water; at 20 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; regioselective reaction;

DOI:10.1021/acs.joc.9b00174

Reference yield: 92.0%

4-bromoisoquinoline (1532-97-4) → 4-iodo-isoquinoline (55270-33-2)

Guidance literature:

With copper(l) iodide; rac-diaminocyclohexane; sodium iodide; In 1,4-dioxane; at 110 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1258399

Reference yield: 71.0%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline (685103-98-4) → 4-iodo-isoquinoline (55270-33-2)

Guidance literature:

With copper(I) oxide; 1,10-Phenanthroline; potassium iodide; In methanol; water; at 80 ℃; for 1h; High pressure;

DOI:10.1021/ol303164h

upstream raw materials:

4-bromoisoquinoline

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline

isoquinoline

2-benzylisoquinolin-2-ium iodide

Downstream raw materials:

isoquinoline

(E)-4-(styryl)isoquinoline

(Z)-4-styrylisoquinoline

4-phenylisoquinoline