3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE
• CAS No.: 362609-92-5
• Molecular Formula: C9H8 O5
• Molecular Weight: 196.16
• Mol file: 362609-92-5.mol

Synonyms:3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE;

Chemical Property of 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE

Chemical Property:

• PSA: 61.83000
• LogP: 0.73260
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzo[d][1,3]dioxol-5-yl)-2-oxoacetaldehydehydrate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE

There total 2 articles about 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzo[d][1,3]dioxol-6-yl)ethanone (3162-29-6) → 3,4-(methylenedioxy)phenylglyoxal monohydrate (362609-92-5)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.tet.2012.10.072

Reference yield:

3,4-methylenedioxyphenylglyoxal (65709-23-1) → 3,4-(methylenedioxy)phenylglyoxal monohydrate (362609-92-5)

Guidance literature:

With water; Reflux;

DOI:10.3906/kim-1408-32 DOI:10.1007/s11164-016-2848-5

Reference yield: 87.0%

2-methyl-1H-indole (95-20-5) + 3,4-(methylenedioxy)phenylglyoxal monohydrate (362609-92-5) + dimedone (126-81-8) → C26H23NO5

Guidance literature:

With 7.78 wtpercent Cu supported on porous hypercrosslinked polymer (from N,N'-dibenzylbenzimidazolium chloride and benzene); In ethanol; at 80 ℃; for 4h;

DOI:10.1039/c5cy02260f

upstream raw materials:

1-(benzo[d][1,3]dioxol-6-yl)ethanone

3,4-methylenedioxyphenylglyoxal

Downstream raw materials:

2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl acetate

2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl propionate

2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl isobutyrate

2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl butyrate

Refernces

• 1、 Rimaz, Mehdi,Mousavi, Hossein,Nikpey, Laya,Khalili, Behzad. "Novel and convenient one-pot strategy for regioselective synthesis of new 5-aryl-3-methyl-1-phenyl-1,2-dihydro-7aH-pyrazolo[3,4-c]pyridazin-7a-ol derivatives". . p. 3925 - 3937. Retrieved 2017/06/20.
• 2、 Obijalska, Emilia,Utecht, Greta,Kowalski, Marcin K.,Mlostoń, Grzegorz,Rachwalski, Micha?. "Nucleophilic addition of (difluoromethyl)trimethylsilane to selected α-imino ketones and aryl diketones". . p. 4701 - 4703. Retrieved 2015/07/28.