1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole

Base Information

• Chemical Name: 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole
• CAS No.: 940948-30-1
• Molecular Formula: C13H8 Cl I N2 O2 S
• Molecular Weight: 418.642
• Hs Code.: 2933990090
• Mol file: 940948-30-1.mol

Synonyms:1-BENZENESULFONYL-4-CHLORO-2-IODO-7-AZAINDOLE;4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1-benzenesulfonyl-4-chloro-2-iodo-1H-pyrrolo-[2,3-b]pyridine;1-(Benzenesulfonyl)-4-chloro-2-iodo-pyrrolo[2,3-b]pyridine;1-(Phenylsulphonyl)-4-chloro-2-iodo-7-azaindole;

Chemical Property of 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole

Chemical Property:

• Vapor Pressure: 9.03E-12mmHg at 25°C
• Melting Point: 135 °C
• Boiling Point: 541oC at 760 mmHg
• PKA: 1.20±0.30(Predicted)
• Flash Point: 281oC
• PSA: 60.34000
• Density: 1.91g/cm3
• LogP: 4.61210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

1-(Benzenesulfonyl)-4-chloro-2-iodopyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole

There total 2 articles about 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine (744209-63-0) → 4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (940948-30-1)

Guidance literature:

1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With iodine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Reference yield:

1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine (744209-63-0) → 4-chloro-2-iodo-1-(2-iodobenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (940948-31-2) + 4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (940948-30-1)

Guidance literature:

1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With iodine; In tetrahydrofuran; at -78 ℃; for 4h;

Reference yield: 90.0%

4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (940948-30-1) + 3-acetylenephenylamine (54060-30-9) → 3-((4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)ethynyl)aniline (1173657-11-8)

Guidance literature:

With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In water; at 80 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2009.04.054

upstream raw materials:

1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

5-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)pent-4-yn-2-ol

6-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)hex-5-ynenitrile

5-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)pent-4-yn-1-ol

3-((4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)ethynyl)aniline

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