(1S)-1-(4-METHYLPHENYL)PENTYLAMINE

Base Information

• Chemical Name: (1S)-1-(4-METHYLPHENYL)PENTYLAMINE
• CAS No.: 1213847-38-1
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.29
• Mol file: 1213847-38-1.mol

Synonyms:

Chemical Property of (1S)-1-(4-METHYLPHENYL)PENTYLAMINE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)-1-(4-METHYLPHENYL)PENTYLAMINE

There total 5 articles about (1S)-1-(4-METHYLPHENYL)PENTYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-<1-methyl-2-<(1R)-1-(4-methylphenyl)pentyl>hydrazino>butan-1-ol → (R)-1-(4-methylphenyl)pentan-1-amine (239105-48-7,1213847-38-1) + (S)-1-(4-methylphenyl)pentan-1-amine (1213847-38-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 110 - 120 ℃; for 5h; under 4500.36 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(99)00146-9

Reference yield:

(2R)-2-<1-methyl-2-<(1R)-1-(4-methylphenyl)pentyl>hydrazino>butan-1-ol → (R)-1-(4-methylphenyl)pentan-1-amine (239105-48-7,1213847-38-1) + (S)-1-(4-methylphenyl)pentan-1-amine (1213847-38-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 110 - 120 ℃; for 5h; under 4500.36 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(99)00146-9

Reference yield:

4-methylbenzenecarbaldehyde-N-<(1R)-1-(hydroxymethyl)propyl>-N-methylhydrazone → (R)-1-(4-methylphenyl)pentan-1-amine (239105-48-7,1213847-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) ether, reflux, 3 h, 2.) ether, reflux, 16 h

2: H₂, conc. HCl / 10 percent Pd/C / ethanol / 5 h / 110 - 120 °C / 4500.36 Torr

With hydrogenchloride; hydrogen; magnesium; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0957-4166(99)00146-9

upstream raw materials:

n-butyllithium

4-methyl-benzaldehyde

Refernces

• 1、 Katritzky, Alan R.,Xie, Linghong,Zhang, Guifen,Griffith, Michael,Watson, Karen,Kiely, John S.. "Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support". . p. 7011 - 7014. Retrieved 2007/10/03.