diethyl methylenepropanedioate

Base Information

• Chemical Name: diethyl methylenepropanedioate
• CAS No.: 156335-46-5
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.368
• Mol file: 156335-46-5.mol

Synonyms:

Chemical Property of diethyl methylenepropanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl methylenepropanedioate

There total 1 articles about diethyl methylenepropanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-phenyl-1H-pyrrol-1-amine (72618-06-5) + diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl methylenepropanedioate (156335-46-5)

Guidance literature:

at 150 ℃; for 4h;

DOI:10.1002/jhet.5570310228

Reference yield: 46.0%

diethyl methylenepropanedioate (156335-46-5) → ethyl 1,4-dihydro-4-oxo-1-phenylpyrrolo<1,2-b>pyridazine-3-carboxylate (156335-47-6)

Guidance literature:

With PPA; at 80 ℃; for 2h;

DOI:10.1002/jhet.5570310228

Reference yield:

diethyl methylenepropanedioate (156335-46-5) → 1,4-dihydro-4-oxo-1-phenylpyrrolo<1,2-b>pyridazine-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / polyphosphoric acid / 2 h / 80 °C

2: 43 percent / 2 N NaOH / ethanol / 0.5 h

With sodium hydroxide; PPA; In ethanol;

DOI:10.1002/jhet.5570310228

upstream raw materials:

N-phenyl-1H-pyrrol-1-amine

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

ethyl 1,4-dihydro-4-oxo-1-phenylpyrrolo<1,2-b>pyridazine-3-carboxylate