H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH

Base Information

Chemical Name:H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH
CAS No.:131696-83-8
Molecular Formula:3C₂H₄O₂*C₃₆H₆₁N₁₃O₈
Molecular Weight:984.12
Hs Code.:

Synonyms:

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Chemical Property of H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH

Chemical Property:

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Technology Process of H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH

There total 9 articles about H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39614-17-0,128557-46-0,145313-30-0
L-valyl-L-phenylalanine methyl ester

: 131696-83-8
H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH

Guidance literature:: Multi-step reaction with 8 steps

1: 71.3 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / 4 °C

2: catalytic hydrogenation

3: 89.6 percent / NEt₃ / dimethylformamide / Ambient temperature

4: catalytic hydrogenation

5: 80.7 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / 4 °C

6: catalytic hydrogenation

7: 71.8 percent

8: 1) methanesulfonic acid, anisole, m-cresole, 2) Amberlite IRA 45 (acetate form) / 1a) 0 deg C, 30 min, b) r.t., 90 min, 2) 30 min

With methanesulfonic acid; Amberlite IRA 45 (acetate form); diphenylphosphoranyl azide; 3-methyl-phenol; methoxybenzene; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2369

Reference yield:

: 4817-95-2
N-(benzyloxycarbonyl)-L-valyl-L-phenylalanine methyl ester

: 131696-83-8
H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH

Guidance literature:: Multi-step reaction with 9 steps

1: catalytic hydrogenation

2: 71.3 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / 4 °C

3: catalytic hydrogenation

4: 89.6 percent / NEt₃ / dimethylformamide / Ambient temperature

5: catalytic hydrogenation

6: 80.7 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / 4 °C

7: catalytic hydrogenation

8: 71.8 percent

9: 1) methanesulfonic acid, anisole, m-cresole, 2) Amberlite IRA 45 (acetate form) / 1a) 0 deg C, 30 min, b) r.t., 90 min, 2) 30 min

With methanesulfonic acid; Amberlite IRA 45 (acetate form); diphenylphosphoranyl azide; 3-methyl-phenol; methoxybenzene; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2369

Reference yield:

: H-Val-Arg(Mts)-Val-Phe-OMe

: 131696-83-8
H-Asn-Arg-Val-Arg-Val-Phe-OMe*3AcOH

Guidance literature:: Multi-step reaction with 4 steps

1: 80.7 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / 4 °C

2: catalytic hydrogenation

3: 71.8 percent

4: 1) methanesulfonic acid, anisole, m-cresole, 2) Amberlite IRA 45 (acetate form) / 1a) 0 deg C, 30 min, b) r.t., 90 min, 2) 30 min

With methanesulfonic acid; Amberlite IRA 45 (acetate form); diphenylphosphoranyl azide; 3-methyl-phenol; methoxybenzene; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2369