Methyl-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: Methyl-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester
• CAS No.: 1334335-95-3
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.308
• European Community (EC) Number: 845-825-4
• Mol file: 1334335-95-3.mol

Synonyms:1334335-95-3;Methyl-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester;tert-butyl N-methyl-N-(pyrrolidin-2-ylmethyl)carbamate;tert-Butyl methyl(pyrrolidin-2-ylmethyl)carbamate;tert-butyl N-methyl-N-[(pyrrolidin-2-yl)methyl]carbamate;(R)-tert-butylmethyl(pyrrolidin-2-ylmethyl)carbamate;SCHEMBL16529770;AKOS023771995;AM91888;PS-18080;CS-0264769;FT-0773321;EN300-94412;E88350;tert-Butyl methyl(2-pyrrolidinylmethyl)carbamate;tert-Butylmethyl(pyrrolidin-2-ylmethyl)carbamate;methylpyrrolidin-2-ylmethylcarbamic acid tert-butyl ester;Z1268632936

Chemical Property of Methyl-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.168127949
• Heavy Atom Count: 15
• Complexity: 223

Purity/Quality:

97% ^*data from raw suppliers

tert-butylN-methyl-N-(pyrrolidin-2-ylmethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N(C)CC1CCCN1

Technology Process of Methyl-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester

There total 14 articles about Methyl-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (2R)-2-[[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]methyl]pyrrolidine-1-carboxylate → (R)-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine (1334335-95-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 15h; Inert atmosphere;

Reference yield: 55.0%

(S)-1-benzyl-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine (172477-90-6) → (S)-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine (172477-91-7,1334335-95-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1016/0040-4020(95)00716-L

Reference yield:

(R)-1-benzyl-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine → (R)-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine (1334335-95-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1016/0040-4020(95)00716-L

upstream raw materials:

(S)-1-benzyl-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine

di-tert-butyl dicarbonate

N-benzyl-L-proline ethyl ester

(S)-1-benzyl-2-methylaminomethyl-pyrrolidine

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